Corey Speers, M.D., Ph.D.
Assistant Professor of Radiation Oncology
Dr. Corey Speers is a board certified radiation oncologist and assistant professor in the Department of Radiation Oncology at the University of Michigan Health System. He completed his medical and graduate school training at Baylor College of Medicine and M.D. Anderson Cancer Center in Houston, Texas before moving to the University of Michigan Health System to complete his residency and fellowship training in Radiation Oncology. After completing training he joined the faculty as a clinician scientist in the Department of Radiation Oncology.
Our laboratory research includes nomination and validation of expression-based signatures to predict patients that need treatment intensification and signatures to identify patient who will not need further adjuvant therapy for breast cancer. Moreover, our translational work has credentialed a number of novel targets for the treatment of estrogen and progesterone receptor-negative, HER2-negative “triple-negative” breast cancer, a particularly aggressive and difficult to treat form of breast cancer. As PI or co-Investigator on several university-, industry-, private foundation- and NIH-funded grants, we remain active in the radiation and breast cancer research arena by looking for more effective, targeted therapies for women with breast cancer. These targeted therapies include PARP-inhibitors, BET bromodomain inhibitors, and androgen receptor antagonists as agents for radiatiosensitization. We have also utilized kinome screens to identify novel targets for the treatment of aggressive breast cancers, including triple-negative breast cancer. We are also interested in the mechanisms of treatment resistance that include modulation of breast tumor initiating cells and understanding novel layers of cancer biology, including the role of long non-coding RNA in triple-negative breast cancer.