David Beer, Ph.D.

John and Carla Klein Professor of Thoracic Surgery

Biography

David G. Beer Ph.D. is Professor of Surgery and Professor of Radiation Oncology at the University of Michigan. He received a B.S. in biology in 1975 from Northeastern Illinois University and a Ph.D. in biochemical pharmacology at University of Colorado at Boulder in 1984. Dr. Beer completed post-doctoral training in molecular oncology at the McArdle Laboratory for Cancer Research, University of Wisconsin, Madison from 1984 to 1987. In 1987 Dr. Beer became an Assistant Professor in Pharmacology, Toxicology and Therapeutics at the University of Kansas Medical School in Kansas City, KS.

In 1991 he joined the faculty at the University of Michigan Medical School in Ann Arbor, as Assistant Professor in both Surgery and Radiation Oncology. He is the Director of the Thoracic Oncology Research Laboratory. In 1994 he was promoted to Associate Professor and to Professor in both Departments in 2001.

Dr. Beer is Co-Director of the Cancer Genetics Program for the University of Michigan Comprehensive Cancer Center and has served on numerous committees within the University and the Cancer Center. He is an Associate Editor for Carcinogenesis, Translational Oncology, Translational Research, Journal of Thoracic Oncology, and Annals of Translational Medicine and serves as a reviewer for many journals including Nature Medicine, New England Journal of Medicine, Carcinogenesis, Gastroenterology, PLOS, Molecular Medicine, Neoplasia, Journal of Clinical Oncology in addition to the AACR journals. Dr. Beer has published over 200 peer-reviewed original research articles and has focused on two main research areas currently funded by NIH: the molecular genetics of human lung cancer and the molecular characterization of genes critical to human esophageal adenocarcinoma development. He has pioneered the use of gene and protein expression profiling for the identification of patients with high-risk early stage lung cancers

Research Interests

My laboratory is identifying the mechanisms underlying the progression of Barrett’s metaplasia to adenocarcinoma and new markers that can be utilized for imaging-based early detection. We are also characterizing mRNA and miRNA associated with lung cancer development and progression.

Publications

Nadal E, Zhong J, J Lin, RM Reddy, N Ramnath, MB Orringer, AC Chang, DG Beer, G Chen. A MicroRNA Cluster at 14q32 Drives Aggressive Lung Adenocarcinoma. Clin Cancer Res 2014 May 15 Epub ahead of print. PMID: 24833665.

Cancer Genome Atlas Research Network. Comprehensive Molecular Profiling of Lung Adenocarcinoma. Nature Jul 31;511(7511):543-50. doi: 10.1038/nature13385. Epub 2014 Jul 9.PMID:25079552.

Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014 Jul 23. doi: 10.1038/nature13480. [Epub ahead of print]PMID:25079317.

Dhanasekaran SM, OA Balbin, G Chen, E Nadal, S Kalyana-Sundaram, J Pan, B Veeneman, X Cao, R Wang, S Huang, J Zhong, X Jing, P Vats, M Iyer, YM Wu, PW Harms, JLin, R Reddy, N Palanisamy, AC Chang, A Truini, M Truini, DR Robinson, DG Beer, AM Chinnaiyan. Transcriptome Meta-Analysis of Lung Cancer Reveals Recurrent Aberrations in NRG1, NF1, MET and Hippo Pathway Genes. Nature Communications. 22 Dec 2014.

Iyer MK, YS Niknafs, TR Barrette, A Sahu, R Malik, JR Evans, JR Prensner, X Cao, SM Dhanasekaran, YM Wu, DR Robinson, DG. Beer, FY Feng, HK Iyer, AM Chinnaiyan. The Landscape of Long Non-Coding RNAs in Cancer. Nature Genetics 2015 Jan 19. doi: 10.1038/ng.3192. [Epub ahead of print]PMID:25599403

Bowman BM, BA Hoff, JL Boes, KA Heist, CJ Galban, RM Patel, J Zhang, DG Beer, BD Ross, A Rehemtulla, S Galban. A Requirement for FADD and its Phosphorylation for KRAS-Driven Oncogenesis. Science Signaling. 2015 Jan 27;8(361) (cover issue). PMID: 25628462

Balbin OA, R Malik, SM. Dhanasekaran, J Prensner, X Cao, YM Wu, D Robinson, R Wang, G Chen, DG. Beer, AI Nesvizhskii, AM Chinnayian. The Landscape of antisense gene expression in human cancers. Genome Research June 2015 adv. publication.

He Y, L Wang, W Liu, J Zhong, S Bai, Z Wang, DG Thomas, J Lin, RM Reddy, N Ramnath, PW Carrott, Jr., WR Lynch, MB Orringer, AC Chang, DG Beer, G Chen. MAP3K3 expression in tumor cells and tumor-infiltrating lymphocytes is correlated with favorable patient survival in lung cancer. Scientific Reports Jun 19, 2015; 5:11471. PMID: 26088427.

Goswami MT, G Chen, BVSK Chakravarthi, SS Pathi, SK Anand, SL Carskadon, TJ Giordano, AM Chinnaiyan, DG Thomas, N Palanisamy, DG Beer, S Varambally. Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer. Oncotarget Jun 23 2015. PMID: 26140362

Stachler MD, Taylor-Weiner A, S Peng, A McKenna, I Leshchiner, C Stewart, P Stojanov, S Chauvin, MS Lawrence, D Ferrer Torres, J Lin, A Chang, SB Gabriel, ES Lander, DG Beer, SL Carter, G Getz, AJ Bass.. Paired Exome Analysis of Barrett’s Esophagus and Adenocarcinoma Reveals Distinct Paths to Cancer. Nature Genetics (in press).

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