David Lombard, M.D., Ph.D.

Associate Professor of Pathology

Biography

Dr. Lombard received a Ph.D. in Biology from Massachusetts Institute of Technology (2000) and an M.D. from Harvard Medical School (2001). He completed residency training in Anatomic Pathology (2001-2003) at Brigham and Women's Hospital in Boston. Following residency training Dr. Lombard joined the laboratory of Professor Frederick Alt at Children's Hospital as a Posdoctoral Fellow. He continued in this role until joining the faculty of the Department of Pathology in September 2008.

Dr. Lombard joined the faculty of the University of Michigan as an Assistant Professor in the Department of Pathology and hold a joint appointment in the Institute of Gerontology as Research Assistant Professor.

Research Interests

Sirtuin deacylases and their relationships with cancer and other age-associated diseases.

Publications

Kumar S, Lombard DB. Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal 2015; epub ahead of print.

Giblin W, Skinner ME, Lombard DB: Sirtuins: guardians of mammalian healthspan TIG 30(7): 271-86, 2014. PMC 4077918.

Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Muhlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y. Lysine glutarylation is a novel protein modification pathway regulated by SIRT5. Cell Metab 2014; 19(4):605-617. PMC 108075.

Zwaans BMM, Lombard DB. Interplay between sirtuins, c-MYC, and hypoxia-inducible factor in cancer-associated metabolic reprogramming. DMM 7(9):1023-1032, 2014. PMC 4142723.

Lombard DB, Zwaans BMM. SIRT3: as simple as it seems? Gerontology 2014 60(1):56-64. PMCID 3875292.

Park J*, Chen Y*, Tishkoff D, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BMM, Skinner ME, Lombard DB+, Zhao Y+. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell 2013; 50(6):919-30. PMC 3769971.

Sebastian C, Zwaans BMM, Silberman M, Zhong L, Toiber D, Martinez B, Cosentino C, Etchegaray J-P, Giacosa S, Goren A, Gimrek A, Truelove J, Greenson J, Lombard DB+, Mostoslavsky R+. The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell 2012; 157(6):1185-1199. PMC 3526953.

Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Ravindra PV, Pillai VB, Gupta M, Cunningham JM, Deng C-X, Lombard DB, Mostoslavsky R, Gupta MP. The SIRT6 deacetylase plays an essential role in regulating IGF-Akt signaling and the development of aging associated heart failure. Nature Med. 2012; 18(11):1643-50.

Chiang W-C, Tishkoff DX, Yang B, Wilson-Grady J, Mazer T, Eckersdorff ME, Gygi SP, Lombard DB+, Hsu A-L+. C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. PLoS Genet 2012; 8(9):e1002948. PMCID 3441721.

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