David Markovitz, M.D.

Professor of Internal Medicine, Division of Infectious Diseases

Research Interests

Our laboratory studies the interaction between human cellular factors and retroviruses, and their role in oncogenesis and immunity

Publications

Ferir, G., Huskens, D., Palmer, K.E., Boudreaux, D.M., Swanson, M.M., Markovitz, D.M., Balzarini, J., and Schols, D. Combinations of griffithsin with other carbohydrate-binding agents (CBAs) demonstrate superior activity against HIV-1, HIV-2 and selected CBA-resistant HIV-1 strains. AIDS Res Hum Retroviruses 2012; 28(11):1513-23. PMCID: PMC3484736.

Patel, R.M., Walters, L.L., Kappes, F., Mehra, R., Fullen, D.R., Markovitz, D.M., and Ma, L. DEK expression in Merkel cell carcinoma and small cell carcinoma. J. Cutan. Pathol. 2012; 39(8):753-7.

Monde, K., Contreras-Galindo, R., Kaplan, M.H., Markovitz, D.M., and Ono, A. HERV-K Gag coassembles with HIV-1 Gag and reduces the release efficiency and infectivity of HIV-1. J. Virol. 2012; 86(20):11194-208. PMCID: PMC3457174.

Mor-Vaknin, N., Legendre, M., Yue, Y., Serezani, C.H.C., Garg, S.K., Jatzek, A., Swanson, M.D., Gonzalez-Hernandez, M.J., Teitz-Tennenbaum, S., Punturieri, A., Engleberg, N.C., Banerjee, R., Peters-Golden, M., Kao, J.Y., and Markovitz, D.M. Murine colitis is mediated by vimentin. Sci. Rep. 2013; 3:1045. PMCID:PMC3540396.

Saha, A.K., Kappes, F., Mundade, A., Deutzmann, A., Rosmarin, D., Legendre, M., Chatain, N., Al-Obaidi, Z., Adams, B.S., Ploegh, H., Ferrando-May, E., Mor-Vaknin, N.*, and Markovitz, D.M.* Intercellular trafficking of the nuclear oncoprotein DEK. Proc. Natl. Acad. Sci., USA. 2013; 110(17):6847-52. PMCID: PMC3637753.

Contreras-Galindo, R., Kaplan, M.H., He, S., Contreras-Galindo, A.C., Gonzalez-Hernandez, M.J., Kappes, F., Dube, D., Chan, S.M., Robinson, D., Meng, F., Dai, M., Gitlin, S.D., Chinnaiyan, A.M., Omenn, G.S. and Markovitz, D.M. HIV infection reveals wide-spread expansion of novel centromeric human endogenous retroviruses. Genome Res., 2013; 23(9):1505-13. PMCID: PMC3759726.

Broxmeyer, H.E., Mor-Vaknin, N., Kappes, F., Legendre, M., Saha, A.K., Ou, X., O’Leary, H.A., Capitano, M., Cooper, S., and Markovitz, D.M. A role for DEK in stem/progenitor cell biology. Stem Cells, 2013; 31(8):1447-53. PMCID: PMC3814160.

Gonzales-Hernandez, M.J., Cavalcoli, J.D., Sartor, M.A., Contreras-Galindo, R., Fan, M., Manhong, D., Dube, D., Saha, A.K., Gitlin, S.C., Omenn, G.S., Kaplan, M.H., and Markovitz, D.M. Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein. J. Virol., 2014 (In Press).

Dube, D., Contreras-Galindo, R., He, S., King, S.R., Gonzalez-Hernandez, M.J., Gitlin, S.D., Kaplan, M.H., and Markovitz, D.M. Genomic Flexibility of Human Endogenous Retrovirus Type K. J. Virol., 2014 (In Press).

Logan, G.E., Mor-Vaknin, N., Braunschweig, T., Jost, E., Schmidt, P.V., Markovitz, D.M., Mills, K.I., Kappes, F., and Percy, M.J. DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML). Blood Cells, Molecules, and Diseases, 2014. DOI: 10.1016/j.bcmd.2014.07.009.

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