Jacques is the Donald Kerr Endowed Professor of Dentistry and serves as Chair of the Department of Cariology, Restorative Sciences and Endodontics at the University of Michigan School of Dentistry. He has joint appointments as Professor of Otolaryngology (Medical School) and Professor of Biomedical Engineering (College of Engineering) at the University of Michigan. Jacques serves as Chair of the Oral Dental and Craniofacial Sciences (ODCS) NIH study section, and has been the principal investigator for several NIH grants. He has served as the Co-Director of the University of Michigan Head Neck SPORE funded by the National Cancer Institute (NCI). Jacques is an elected Fellow of the American Association for the Advancement of Sciences (AAAS) and recently became Fellow of the American Association for Dental Research (AADR). He received the Distinguished Scientist Award and the William J. Gies Award from the International Association for Dental Research (IADR). Jacques is Associate Editor of the Journal of Dental Research and a member of several editorial boards.
Our research interests are in the study of the pathobiology of cancer stem cells in head neck squamous cell carcinoma and salivary gland cancer, as well the understanding of mechanisms regulating mesenchymal stem cell differentiation
Krishnamurthy S, Meyers K, Dong Z, Imai A, Ward B, Helman JI, Taichman R, Bellile EL, McCauley L, Polverini PJ, Prince ME, Wicha MS, Nör JE. Endothelial IL-6 defines the tumorigenic potential of human head and neck cancer stem-like cells. Stem Cells 2014 Jul 30. doi: 10.1002/stem.1793. [Epub ahead of print].
Zhang Z, Dong Z, Lauxen I, Sant’Anna M, Nör JE. Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype. Cancer Res 74(10):2869-2881, 2014.
Nor C, Zhang Z, Warner KA, Bernardi L, Visioli F, Helman J, Roesler R, Nör JE. Cisplatin induces Bmi-1 and enhances the stem cell fraction in head and neck cancer. Neoplasia 16(2): 137–146, 2014.
Warner KA, Adams A, Bernardi L, Nor C, Herwig K, Zhang Z, McLean SA, Helman J, Wolf GT, Divi V, Queimado L, Kaye FJ, Castilho RM, Nör JE. Characterization of tumorigenic cell lines from the recurrence and lymph node metastasis of a human salivary mucoepidermoid carcinoma. Oral
Oncol 49(11):1059-66, 2013.
Adams A, Warner K, Nör JE. Salivary Gland Cancer Stem Cells. Oral Oncol 49(9):845-53, 2013.