Kenneth Cadigan, Ph.D.

Professor of Molecular, Cellular, and Developmental Biology

Biography

Dr. Cadigan received his Ph.D. degree from Dartmouth University in 1989 and has been a postdoctoral fellow at the University of Basel, Switzerland and Stanford University.

Research Interests

My laboratory is exploring the mechanism by which Wnt signaling regulates target gene expression, using Drosophila as a model system.

Publications

Archbold, H.A., Broussard, C., Chang, M.V. and Cadigan, K.M. (2014) Bipartite recognition of DNA by TCF/Pangolin is remarkably flexible and contributes to transcriptional responsiveness and tissue specificity of Wingless signaling.  PLOS Genetics, in press.

Zhang, C.U., Blauwkamp T.A., Burby, P.E., and Cadigan, K.M. (2014) Wnt-mediated repression via bipartite DNA recognition by TCF in the Drosophila hematopoietic system.  PLOS Genetics 10: e1004509.

Bhambhani, C. Ravindranath, A.J., Mentink, R.A., Chang M.V., Betist, M.C., Yang, Y.X., Koushika, S.P., Korswagen, H.C. and Cadigan, K.M. (2014) Distinct DNA binding sites contribute to the TCF transcriptional Switch in C. elegans and Drosophila.  PLOS Genetics 10: e1004133.  PMCID: PMC3916239

Ravindranath, A.J. and Cadigan, K.M. (2014) Structure-Function Analysis of the C-clamp of TCF/Pangolin in Wnt/beta-catenin
Signaling.  PLOS ONE 9: e86180.  PMCID: PMC3896468

Cadigan, K.M. and Waterman, M.L. (2012) TCF/LEFs and Wnt signaling in the nucleus.  Cold Spring Harb. Perspect. Biol. 4: a007906.

Archbold, H.A., Yang, Y.X., Chen, L. and Cadigan, K.M. (2012) How can they do Wnt they do: regulation of transcription by Wnt/beta-catenin signaling.  Acta Physiologica, 204: 74-109.

Bhambhani, C., Chang, J.L., Akey, D.L. and Cadigan, K. M. (2011) The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets. EMBO J. 30: 2031-2043. PMCID: PMC3098475

Chang, M.V., Chang, J.L., Gangopadhyay, A., Shearer, A. and Cadigan, K.M. (2008) Activation of Wingless targets requires bipartite recognition of DNA by TCF. Curr. Biol. 18: 1877-1881. PMCID: PMC3105462
 
Kennell, J. Gerin, I., MacDougald, O.A. and Cadigan, K. M. (2008) The microRNA miR-8 is a conserved negative regulator of Wnt signaling.  Proc. Natl. Acad. Sci. USA 105: 15417-15422. PMCID: PMC2563117.

Blauwkamp, T.A., Chang, M.V. and Cadigan, K.M. (2008) Novel TCF Binding Sites Specify Transcriptional Repression by Wnt Signaling.  EMBO J. 27:1436-1446. PMCID: PMC18418383

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