Mark Chiang, M.D., Ph.D.

Associate Professor of Internal Medicine, Hematology/Oncology

Research Interests

Our lab is committed to defining the molecular signals that drive induction and maintenance of childhood leukemia. We study strategies to selectively target the oncogenic functions of Notch signaling as opposed to its physiological and tumor suppressor functions.


Rakowski, L.A., Lehotzky, E.A., Chiang, M.Y. Transient Responses toNOTCH and TLX1/HOX11 Inhibition in T-cell Acute LymphoblasticLeukemia/Lymphoma. PLoS ONE. 6:e16761, 2011. PMID: 21326611. PMCID:PMC3033898.
Liu, H., Chiang, M.Y.*, Pear, W.S. CriticalRoles of NOTCH1 in Acute T-cell LymphoblasticLeukemia/Lymphoma. Int. J. ofHematology. 2:118-25, 2011. PMID: 21814881.

Kiel,M.J., Velusamy, T., Betz, B.L., Zhao, L., Weigellin, H.G., Chiang, M.Y., Huebner-Chan, D.R., Bailey, N.G., Yang, D.T., Bhagat,G., Miranda, R.N., Bahler, D.W., Medeiros, L.J., Lim, M.S., Elenitoba-Johnson,K.S.J. Whole genome sequencing identifies recurrent somatic NOTCH2 mutations insplenic marginal zone lymphoma. Journal of Experimental Medicine. 209:1553-1551, 2012. PMID: 22891276. PMCID: PMC3428949.

Giambra, V., Jenkins, C.R., Wang,H., Lam, S., Shevchuk, O., Nemirovsky, O., Wai, C., Gusscott, S., Chiang, M.Y., Aster, J.C., Humphries,R.K., Eaves, C., Weng, A.P. PKCθRegulates T-Cell Leukemia-Initiating Activity via Reactive Oxygen Species.Nature Medicine. Nature Medicine. 11: 1693-8, 2012. PMID: 23086478. PMCID: PMC3738873.

Chiang, M.Y.*, Shestova, O., Xu, L., Aster, J.C., Pear, W.S.Divergent effects of supraphysiological Notch signals on leukemia stem cells and hematopoietic stem cells. Blood. 121: 905-17, 2013. PMID: 23115273.

Rakowski, L.A., Garagiola, D.G.,Li, C.M., Decker, M., Caruso, S., Jones, M., Kuick, R., Cierpicki, T., Maillard, I., and Chiang, M.Y. Convergence of the ZMIZ1 and NOTCH1pathways at C-MYC in acute T lymphoblastic leukemias. Cancer Research. 73: 930-41, 2013. PMID: 23161489. PMCID: PMC3549029.

Pinnell NE and Chiang MY. Collaborating Pathways that Functionally Amplify NOTCH1 Signals in T-Cell Acute Lymphoblastic Leukemia. J Hematol Transfus. 2013. 1: 1004.