Elizabeth Lawlor, M.D., Ph.D.
Russell G. Adderley Professor of Pediatric Oncology
Professor, Departments of Pediatrics and Pathology
Elizabeth (Beth) R. Lawlor, MD, PhD, completed her clinical training in Pediatrics and Pediatric Hematology-Oncology in Canada before embarking on post-doctoral research training at the University of California, San Francisco. She began her independent lab at Children’s Hospital Los Angeles and, since 2010, she has been at the University of Michigan. As a dual-trained MD and PhD physician-scientist, Dr. Lawlor is committed to educating the next generation of basic and translational researchers and is dedicated to graduate and post-graduate education in the areas of cancer biology and pediatric oncology. She is the associate director for education and training at the Rogel Cancer Center.
The central hypothesis underlying Dr. Lawlor's research is that pediatric cancers, in particular Ewing sarcoma, stem from hijacked regulation of developmental programs that are intrinsic to normal embryogenesis. The overall goal of her lab is to discover and define differences between normal and cancer cell biology in order to enable development of targeted therapeutics. To achieve this her lab uses diverse cell and animal models, and collaborates actively with experts in developmental biology, epigenetics, metabolism, and drug development. Current projects in the lab are focused on tumor cell heterogeneity as a mediator of Ewing sarcoma metastasis and the specific roles of HOX genes, menin, and the Wnt/beta catenin pathway on tumor pathogenesis. Her lab has been continuously funded by grants from the NCI, Alex's Lemonade Stand Foundation, AACR/SU2C, the St. Baldrick's Foundation, and numerous smaller foundations.