Sami Malek, MD

Professor, Internal Medicine - Division of Hematology/Oncology

Research Interests

Overall, the major research directions I will take over the next 5-10 years are:

Genomic and biological characterization  of Follicular Lymphoma

Pre-clinical to clinical targeted therapy development in FL

Identification of drivers of therapy failure to conventional and targeted therapies in various hematological malignancies and clinical application of such knowledge         

Identification of novel genes that underlie the biology of various structural genomic changes in CLL, AML and FL

Minimal residual disease (MRD) monitoring in leukemia and development of MRD- guided novel innovative clinical trials. Identification of p53 apoptotic network defects in AML


Shedden K, Li Y, Ouillette P, Malek S N: Characteristics of chronic lymphocytic leukemia with somatically acquired mutations in NOTCH1 exon 34. Leukemia 26(5): 1108-10, 2012. PM22182918/PMC3634572

Parkin B, Ouillette P, Li Y, Keller J, Lam C, Roulston D, Li C, Shedden K, Malek SN: Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia. Blood 121(2): 369-377, 2013. PM23175688/PMC3653567

Malek SN: The biology and clinical significance of acquired genomic copy number aberrations and recurrent gene mutations in chronic lymphocytic leukemia. Oncogene 32(23): 2805-17, 2013. PM23001040/PMC3676480

Ouillette P, Saiya-Cork K, Seymour E, Li C, Shedden K, Malek SN: Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia. Clin. Cancer Res. 19(11): 2893-904, 2013. PM23620403/PMC3674194

Li H, Kaminski MS, Li Y, Yildiz M, Ouillette P, Jones S, Fox H, Jacobi K, Saiya-Cork K, Bixby D, Lebovic D, Roulston D, Shedden K, Sabel M, Marentette L, Cimmino V, Chang AE, Malek SN: Mutations in linker

histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma Blood 123(10): 1487-1498, 2014. PM24435047/PMC4729540

Parkin B, Ouillette P, Yildiz M, Saiya-Cork K, Shedden K, Malek SN: Integrated genomic profiling, therapy response and survival in adult acute myelogenous leukemia. Clin. Cancer Res. 21(9): 2045-56, 2015. PM25652455/PMC4417381

Yildiz M, Li H, Bernard D, Amin NA, Ouillette P, Jones S, Saiya-Cork K, Parkin B, Jacobi K, Shedden K, Wang S, Chang AE, Kaminski MS, Malek SN: Activating STAT6 mutations in follicular lymphoma. Blood 125(4): 668-79, 2015. PM25428220/PMC4729538

Amin N, Seymour EK, Saiya-Cork K, Parkin B, Shedden K, Malek SN: A quantitative analysis of subclonal and clonal gene mutations pre- and post-therapy in chronic lymphocytic leukemia. Clin. Cancer Res.: 2016. (In Press) PM27060156

Ying ZX, Jin M, Peterson LF, Bernard D, Saiya-Cork K, Yildiz M, Wang S, Kaminski M, Chang A, Klionsky DJ, Malek S: Recurrent mutations in the MTOR regulator RRAGC in follicular lymphoma. Clin. Cancer Res.: 2016. (In Press) PM27267853

Amin N, Balasubramanian S, Saiya-Cork K, Shedden K, Hu N, Malek S: Cell-intrinsic determinants of ibrutinib-induced apoptosis in Chronic Lymphocytic Leukemia. Clin Cancer Res: 2016. PM27535981

Parkin, B., Londono-Joshi, A., Kang, Q., Tewari, M., Rhim, A.D., Malek S.N. (2017). Ultra-sensitive detection of rare aberrant cells in remission causing AML relapse. Journal of Clinical Investigation. 2017 Sep 1;127(9):3484-3495.